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Opioid Withdrawal, Timeline and Risks

As a national epidemic, opioid addiction is claiming the lives of thousands of Americans each year. Many people fear stopping using these dangerous drugs due to the opioid withdrawal timeline and how uncomfortable withdrawal symptoms are. For those struggling with opioid withdrawal, help is available. Getting proper care to get through opioid withdrawal can help to ensure a great start to recovery.

Dangers of Opioid Withdrawal

Withdrawal from opioids can be dangerous. Not only is it an extremely uncomfortable and unpleasant experience, but it can lead to dangerous and life-threatening complications. Due to some of the withdrawal symptoms experienced during the opioid withdrawal timeline, a person who is going through it can experience some complications that could potentially be fatal. Opioids are a class of drug that is mainly used in the treatment of chronic and severe pain. Mostly used after surgery, 12>opioids are highly addictive and often lead to dependence. The body becomes accustomed to these drugs, and eventually higher doses are required to achieve the effects of pain relief, or in those who use them illicitly, higher doses are required to achieve the high they are looking for. When a person becomes dependent on these dangerous drugs and begins using more and more, they can become addicted, in turn resulting in opioid withdrawal symptoms. Illicit drugs like 12>heroin and 12>fentanyl can lead to these symptoms. Opioid withdrawal symptoms include things like: 
  • Nausea
  • Vomiting
  • Restlessness
  • Anxiety
  • Depression
  • Muscle aches
  • Runny nose
  • Watery eyes
  • High blood pressure
  • Dilated pupils
  • Stomach cramps
  • Decreased appetite
  • Diarrhea
Symptoms like vomiting and diarrhea lead to dehydration and increased levels of blood sodium which in turn leads to heart failure. This is how opioid withdrawal can lead to fatal results. 

Opioid Withdrawal Timeline

For those wondering what the opioid withdrawal timeline is and how long it takes to detox from opioids, there is no one size fits all answer. Everyone’s body is different and there are different factors that go into how long opioid withdrawal will take. Things like age, usage, and overall health and wellness factor into a person’s ability to detox from opioids.  With that being said, there is a general opioid withdrawal timeline that can give a general overview of how long opioid withdrawal can take, and how the symptoms will present themselves. First, opioid withdrawal symptoms can begin to present themselves within 12-24 hours of the last use of these dangerous drugs. After about a day, the symptoms tend to peak and feel worse. This is when the more severe symptoms can present themselves. When these severe symptoms are at a high, it can be extremely dangerous for the person enduring them and this is why it is highly suggested to receive professional help when attempting to withdraw from opioids. After about 72 hours the symptoms begin to dissipate and after about a week they can be pretty much gone, and a person can begin to feel normal again. Long after the opioid withdrawal timeline has been completed, a person can begin to feel protracted symptoms, and post acute withdrawal syndrome can occur. Cravings often lead a person back to using the drugs that got them into the predicament of opioid withdrawal to begin with. Proper treatment can help manage the opioid withdrawal timeline symptoms. 

Opioid Withdrawal Risks and Side Effects

A person who attempts to go through opioid withdrawal on their own, or cold turkey, often runs a risk of some severe side effects. As previously stated heart failure can occur as a result of dehydration and increased blood sodium levels. There is also the risk of overdose, both fatal and non-fatal. When a person stops using drugs for any amount of time and then returns to using at the same level they previously were, the body may not be able to process that amount of the drug at a conducive pace, leading to overdose. Being in an environment where the symptoms can be managed helps to prevent this from occurring.

Detox Benefits

The benefits of professional detox are far-reaching. Getting help can make the process of opioid withdrawal and the symptoms of the opioid withdrawal timeline manageable. When the symptoms are managed, a person can begin a life of recovery safely and effectively. Undergoing professional detox also allows someone to learn some essential life skills for combating opioid addiction in the future. Learning these positive coping and life skills can help to create a positive mindset that is crucial to not returning to using these dangerous drugs as a means of coping. Professional help is available and can make a world of difference in the lives of those struggling with opioid addiction.

Safely End Opioid Addiction

Struggling with opioid addiction is a difficult undertaking. Undergoing opioid withdrawal without proper care is extremely dangerous and can lead to fatal results. Getting help as soon as possible can ensure safety and recovery from opioid addiction. If you or a loved one are struggling, reaching out can set you on the path to a healthier lifestyle. Louisville Addiction Center can help. 12>Call us today and begin a life in recovery.
Educational & Informational Use

The content published on Louisville Addiction Center blog pages is intended for general educational and informational purposes related to addiction, substance use disorders, detoxification, rehabilitation, mental health, and recovery support. Blog articles are designed to help readers better understand addiction-related topics and explore treatment concepts, but they are not a substitute for professional medical advice, diagnosis, or individualized treatment planning.

Addiction and co-occurring mental health conditions are complex medical issues that affect individuals differently based on many factors, including substance type, length of use, physical health, mental health history, medications, age, and social environment. Because of this variability, information discussed in blog articles—such as withdrawal symptoms, detox timelines, treatment approaches, medications, relapse risks, or recovery strategies—may not apply to every individual. Reading blog content should not replace consultation with licensed medical or behavioral health professionals.

If you or someone you know is experiencing a medical or mental health emergency, call 911 immediately or go to the nearest emergency room. Emergencies may include suspected overdose, seizures, difficulty breathing, chest pain, severe confusion, hallucinations with unsafe behavior, loss of consciousness, suicidal thoughts, or threats of harm to oneself or others. Louisville Addiction Center blog content is not intended for crisis intervention and should never be used in place of emergency care.

Detoxification from drugs or alcohol can involve serious medical risks, particularly with substances such as alcohol, benzodiazepines, opioids, and certain prescription medications. Withdrawal symptoms can escalate quickly and may become life-threatening without proper medical supervision. Any blog content describing detox, withdrawal, or substance cessation is provided to raise awareness and encourage safer decision-making—not to instruct readers to detox on their own. Attempting self-detox without medical oversight can be dangerous and is strongly discouraged.

Blog articles may discuss various addiction treatment options, including medical detox, residential or inpatient rehab, outpatient programs, therapy modalities, medication-assisted treatment, aftercare planning, and recovery support services. These discussions reflect commonly used, evidence-informed approaches but do not represent guarantees of effectiveness or suitability for every person. Treatment recommendations should always be based on a comprehensive assessment conducted by licensed professionals.

Information related to insurance coverage, treatment costs, or payment options that appears within blog content is provided for general informational purposes only. Insurance benefits vary widely depending on the individual’s plan, carrier, state regulations, and medical necessity criteria. Coverage details may change without notice, and no insurance-related statements on blog pages should be interpreted as a promise of coverage or payment. Louisville Addiction Center encourages readers to contact our admissions team directly to verify insurance benefits and eligibility before making treatment decisions.

Some blog posts may reference third-party studies, external organizations, medications, community resources, or harm-reduction concepts. These references are provided for educational context only and do not constitute endorsements. Louisville Addiction Center does not control third-party content and is not responsible for the accuracy, availability, or practices of external websites or organizations.

Use of Louisville Addiction Center blog pages does not establish a provider–patient relationship. Submitting comments, contacting the center through a blog page, or reading articles does not guarantee admission to treatment or access to services. Recovery outcomes vary, and no specific results are promised or implied.

If you are struggling with substance use, withdrawal symptoms, or questions about treatment, we encourage you to seek guidance from licensed healthcare providers. For personalized information about treatment options or insurance verification, you may contact Louisville Addiction Center directly. For emergencies, call 911 immediately.

→ Sources
  1. Alcohol Rehab Help. (2022). Alcohol statistics in Kentucky. Alcohol Rehab Help. https://alcoholrehabhelp.org/kentucky/alcohol-statistics/
  2. Healthy KY. (n.d.). Drug and alcohol statistics in Kentucky. Healthy Kentucky. https://www.healthyky.org/drug-and-alcohol-statistics-in-kentucky.html
  3. Kentucky Office of Drug Control Policy. (n.d.). An assessment of Kentucky’s substance use disorder crisis. Commonwealth of Kentucky. https://odcp.ky.gov/
  4. Kong, J. (2022). An assessment of alcohol use disorder and treatment [Research brief]. University of Louisville. https://louisville.edu/sphis/departments/cik/docs-and-pdfs-1/Kong_AUD_ResearchBrief_FINALADA.pdf
  5. Substance Abuse and Mental Health Services Administration. (2019). State profile: Kentucky—N-SSATS report. SAMHSA. https://www.samhsa.gov/data/sites/default/files/quick_statistics/state_profiles/NSSATS-KY19.pdf
  6. Substance Abuse and Mental Health Services Administration. (2024). Underage drinking prevention programs in Kentucky. SAMHSA. https://library.samhsa.gov/sites/default/files/kentucky-iccpud-state-report-2024.pdf
  7. Wikipedia. (2025). Casey’s Law (Matthew Casey Wethington Act). In Wikipedia. https://en.wikipedia.org/wiki/Casey%27s_Law
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Portrait of Dr. Vahid Osman, Board-Certified Psychiatrist and Addictionologist
Medically Reviewed By
Dr. Vahid Osman, M.D.
Board-Certified Psychiatrist & Addictionologist
Dr. Vahid Osman is a Board-Certified Psychiatrist and Addictionologist with extensive experience treating mental illness, chemical dependency, and developmental disorders. Dr. Osman trained in Psychiatry in France and in Austin, Texas. Read more.
Portrait of Josh Sprung, L.C.S.W.
Clinically Reviewed By
Josh Sprung, L.C.S.W.
Board-Certified Clinical Social Worker
Joshua Sprung serves as a Clinical Reviewer at Louisville Addiction Center, bringing a wealth of expertise to ensure exceptional patient care. Read more.
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